No início da 4ª Temporada Howard utiliza um braço robótico para seu próprio prazer. Penny ajuda Sheldon com seu primeiro encontro.

4×01 – 23/Sep/10 The Robotic Manipulation

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4×02 – 30/Sep/10 The Cruciferous Vegetable Amplification

Megaupload – Easyshare – Depositfiles

4×03 – 07/Oct/10 The Zazzy Substitution

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4×04 – 14/Oct/10 The Hot Troll Deviation

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4×05 – 21/Oct/10 The Desperation Emanation

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4×06 – 28/Oct/10 The Irish Pub Formulation

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4×07 – 04/Nov/10 The Apology Insufficiency

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4×08 – 11/Nov/10 The 21-second Excitation

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4×09 – 18/Nov/10 The Boyfriend Complexity
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4×10 – 09/Dec/10 The Alien Parasite Hypothesis

Megaupload – Hotfile

4×11 – 16/Dec/10 The Justice League Recombination
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4×12 – The Bus Pants Utilization – 06/Jan/11